Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.

  title={Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.},
  author={Mar{\'i}a J Moreno-Aliaga and Nerea P{\'e}rez-Echarri and Beatriz Marcos-G{\'o}mez and Eduardo Larequi and Francisco J Gil-Bea and Benoit Viollet and Ignacio G{\'i}m{\'e}nez and J Alfredo Mart{\'i}nez and Jes{\'u}s Prieto and Matilde Bustos},
  journal={Cell metabolism},
  volume={14 2},
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines. We observed that ct-1(-/-) mice develop mature-onset obesity, insulin resistance, and hypercholesterolemia despite reduced calorie intake. Decreased energy expenditure preceded and accompanied the development of obesity. Acute treatment with rCT-1 decreased blood glucose in an insulin-independent manner and increased insulin-stimulated AKT phosphorylation in muscle. These changes were associated with stimulation of fatty acid… CONTINUE READING
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