Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.

@article{Stewart2010CardiotoxicityW5,
  title={Cardiotoxicity with 5-fluorouracil and capecitabine: more than just vasospastic angina.},
  author={Tanya V Stewart and Nick Pavlakis and Matt Ward},
  journal={Internal medicine journal},
  year={2010},
  volume={40 4},
  pages={303-7}
}
In this case series we present a variety of different cardiac toxicities with 5-fluorouracil and its pro-drug capecitabine, including myocardial infarction, cardiomyopathy, sinoatrial and atrioventricular node dysfunction, takotsubo cardiomyopathy and QT prolongation with torsade-de pointes ventricular tachycardia. We stress the fact that while vasospasm is a well-recognized side-effect of this class of chemotherapeutic agent, broader cardiotoxicity is commonly seen and an increased awareness… CONTINUE READING

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