Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.

@article{Mandenius2011CardiotoxicityTU,
  title={Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review.},
  author={Carl-Fredrik Mandenius and Daniella M Steel and Fozia Noor and Thomas Meyer and Elmar Heinzle and Julia Asp and Sarina Arain and U R S Kraushaar and Susanne Bremer and Reiner Class and Peter Sartipy},
  journal={Journal of applied toxicology : JAT},
  year={2011},
  volume={31 3},
  pages={191-205}
}
In this article, recent progress in cardiotoxicity testing based on the use of immortalized cell lines or human embryonic stem cell (hESC) derived cardiomyocytes in combination with state-of-the-art bioanalytical methods and sensors is reviewed. The focus is on hESC-derived cells and their refinement into competent testing cells, but the access and utility of other relevant cell types are also discussed. Recent developments in sensor techniques and bioanalytical approaches for measuring… CONTINUE READING

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