Cardiotoxicity of lead at various perfusate calcium concentrations: functional and metabolic responses of the perfused rat heart.

@article{Prentice1985CardiotoxicityOL,
  title={Cardiotoxicity of lead at various perfusate calcium concentrations: functional and metabolic responses of the perfused rat heart.},
  author={R C Prentice and Stephen J. Kopp},
  journal={Toxicology and applied pharmacology},
  year={1985},
  volume={81 3 Pt 1},
  pages={491-501}
}
Equilibrated rat hearts were perfused for 60 min with a standard crystalloid buffer containing either 0.9, 1.8, 3.5, or 5.0 mM Ca with or without added lead (0.3 and 30 microM). Contractile tension (T), rate of tension development (dT/dt), electrocardiographic (EKG), His bundle electrographic (HBE) indices, heart rate (HR), preejection period (PEP), and coronary flow rate (CFR) were recorded as a function of perfusion time. Endpoint analyses of myocardial phosphatic metabolites were performed… CONTINUE READING
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