Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.

@article{Llenas1999CardiotoxicityOH,
  title={Cardiotoxicity of histamine and the possible role of histamine in the arrhythmogenesis produced by certain antihistamines.},
  author={Jes{\'u}s Llenas and I Cardel{\'u}s and A F Heredia and Fernando de Mora and Robert W Gristwood},
  journal={Drug safety},
  year={1999},
  volume={21 Suppl 1},
  pages={33-8; discussion 81-7}
}
Since 1990 it has repeatedly been reported that some histamine H1 receptor antagonists (e.g. terfenadine and astemizole) are able to produce ventricular arrhythmias (e.g. torsade de pointes) when they are given at dosages above the therapeutic range and/or administered together with cytochrome P-450 3A4 inhibitors, such as ketoconazole or erythromycin… CONTINUE READING