Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study

@article{Kosmas2007CardiotoxicityOF,
  title={Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study},
  author={Christos Kosmas and Manolis S Kallistratos and Petros Kopterides and John Syrios and Helias Skopelitis and Nicolaos Mylonakis and Athanasios Karabelis and Nicolas B. Tsavaris},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2007},
  volume={134},
  pages={75-82}
}
Cardiotoxicity associated with 5-Fluorouracil (5FU) administration has been infrequently reported in literature, albeit various series of acute coronary syndromes have recorded a low but definite incidence of the above toxicity. In the present study, patients undergoing 5FU-based and oral capecitabine (Xeloda®)-based chemotherapy were tested for the potential development of cardiac-related symptoms during their administration. Six hundred and forty-four patients entered the study. Those… CONTINUE READING

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