Cardiotoxicity of acetogenins from Persea americana occurs through the mitochondrial permeability transition pore and caspase-dependent apoptosis pathways.

@article{SilvaPlatas2012CardiotoxicityOA,
  title={Cardiotoxicity of acetogenins from Persea americana occurs through the mitochondrial permeability transition pore and caspase-dependent apoptosis pathways.},
  author={Christian I Silva-Platas and Noem{\'i} Garc{\'i}a and Evaristo Fern{\'a}ndez-Sada and Daniel D{\'a}vila and Carmen Hern{\'a}ndez-Brenes and Dariana Rodr{\'i}guez and Gerardo J Garc{\'i}a-Rivas},
  journal={Journal of bioenergetics and biomembranes},
  year={2012},
  volume={44 4},
  pages={461-71}
}
Acetogenins are cell-membrane permeable, naturally occurring secondary metabolites of plants such as Annonaceae, Lauraceae and other related phylogenic families. They belong to the chemical derivatives of polyketides, which are synthesized from fatty acid precursors. Although acetogenins have displayed diverse biological activities, the anti-proliferative effect on human cancer cells has been widely reported. Acetogenins are inhibitors of complex I in the electron transport chain therefore they… CONTINUE READING

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