Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.

  title={Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.},
  author={Christoph Sch{\"o}ber and Efstathios S Papageorgiou and Andreas Harstrick and C Carsten Bokemeyer and Andreas Muegge and Michael Stahl and Hansjochen Wilke and Hubert Poliwoda and Wolfgang Hiddemann and Claus Henning K{\"o}hne-W{\"o}mpner},
  volume={72 7},
BACKGROUND Cardiotoxicity related to the widely used cytotoxic compound 5-fluorouracil (5-FU) is rare compared with the frequency observed with the use of anthracyclines. More effective protocols incorporating active biomodulatory compounds like folinic acid (FA) or combination chemotherapy change type and severity of toxicity as well. The objective of the current study was to assess cardiotoxicity of the combination 5-FU and folinic acid. METHODS The authors' multicenter experience with 390… CONTINUE READING
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