Cardiotoxicity associated with targeting kinase pathways in cancer.

  title={Cardiotoxicity associated with targeting kinase pathways in cancer.},
  author={Howard R Mellor and Alex R Bell and J G Valentin and Ruth A Roberts},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={120 1},
Cardiotoxicity, also referred to as drug-induced cardiac injury, is an issue associated with the use of some small-molecule kinase inhibitors and antibody-based therapies targeting signaling pathways in cancer. Although these drugs have had a major impact on cancer patient survival, data have implicated kinase-targeting agents such as sunitinib, imatinib, trastuzumab, and sorafenib in adversely affecting cardiac function in a subset of treated individuals. In many cases, adverse cardiac events… CONTINUE READING
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