Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS.

@article{Kingwell2010CardiotoxicityAO,
  title={Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS.},
  author={Elaine Kingwell and Maurizio Koch and Brian Leung and Saul H. Isserow and Jacqueline Geddes and Peter Rieckmann and Helen Tremlett},
  journal={Neurology},
  year={2010},
  volume={74 22},
  pages={1822-6}
}
BACKGROUND Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail. OBJECTIVE To evaluate the incidence and potential predictors of adverse events associated with mitoxantrone at the MS Clinic, University of British Columbia, Canada. METHODS Retrospective review of patients treated with mitoxantrone by standard protocol; maximum cumulative dose = 120 mg/m(2). Left ventricular ejection fraction… CONTINUE READING

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