Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.

  title={Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling.},
  author={Xiaoying Zhang and Christopher C. T. Szeto and E. Mei Gao and Mingxin Tang and Jianguo Jin and Q. K. Fu and Catherine A. Makarewich and Xiaojie Ai and Ying Li and Allen Tang and Jenny Wang and Hui Gao and Fang Wang and Xinyi Ge and Satya P Kunapuli and Lin Zhou and Chunyu Zeng and Kevin Yang Xiang and Xiongwen Chen},
  journal={Circulation research},
  volume={112 3},
RATIONALE In the failing heart, persistent β-adrenergic receptor activation is thought to induce myocyte death by protein kinase A (PKA)-dependent and PKA-independent activation of calcium/calmodulin-dependent kinase II. β-adrenergic signaling pathways also are capable of activating cardioprotective mechanisms. OBJECTIVE This study used a novel PKA inhibitor peptide to inhibit PKA activity to test the hypothesis that β-adrenergic receptor signaling causes cell death through PKA-dependent… CONTINUE READING
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