Cardiotoxic actions of doxepin and barium chloride in conscious rabbits.

@article{Mattila1986CardiotoxicAO,
  title={Cardiotoxic actions of doxepin and barium chloride in conscious rabbits.},
  author={Mauri J. Mattila and K. {\'A}nyos and E L Puisto},
  journal={Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement},
  year={1986},
  volume={9},
  pages={
          205-8
        }
}
  • Mauri J. Mattila, K. Ányos, E L Puisto
  • Published 1986
  • Chemistry, Medicine
  • Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
  • Infusion of doxepin (Dx) i.v. to conscious rabbits induced dose dependently cardiac dysrhythmias of varying severity. Attempts to reduce sympathetic tone with diazepam or clonidine failed to modify Dx effects. Activation of the heart with aminophylline sensitized the animals to Dx effects. Infusion of barium chloride (Ba) caused severe ventricular dysrhythmias which were promptly abolished or reduced by verapamil. A subtoxic dose of Dx, but not diazepam, clonidine or taurine, counteracted Ba… CONTINUE READING