Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism.

Abstract

The cardiotonic steroid, ouabain, a specific inhibitor of Na(+),K(+)-ATPase, initiates protein-protein interactions that lead to an increase in growth and proliferation in different cell types. We explored the effects of ouabain on glucose metabolism in human skeletal muscle cells (HSMC) and clarified the mechanisms of ouabain signal transduction. In HSMC… (More)

Topics

Cite this paper

@article{Kotova2006CardiotonicSS, title={Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism.}, author={Olga Kotova and Lubna Al-Khalili and Sara Talia and Catherine Hooke and Olga Fedorova and Alexei Y. Bagrov and Alexander V Chibalin}, journal={The Journal of biological chemistry}, year={2006}, volume={281 29}, pages={20085-94} }