Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium

  title={Cardiotonic effect of Apocynum venetum L. extracts on isolated guinea pig atrium},
  author={Kaoru Irie and Takahiro Sato and Ippei Tanaka and Jun-ichiro Nakajima and Maiko Kawaguchi and Toshiyuki Himi},
  journal={Journal of Natural Medicines},
The effects on guinea-pig heart muscle of extracts of Apocynum venetum L. leaf, root, stem, old stem and Venetron—a polyphenol-rich extract of leaves—were studied by recording the mechanical activity and heart rate of isolated right atria. Cymarin—a cardiac glycoside—was also determined in A. venetum extracts by LC–MS/MS analysis. All extracts examined here showed a weak cardiotonic effect, i.e., induced a contractile response of the isolated atria and increased the pulse at a concentration of… 

Cardiotonic effects of cardiac glycosides from plants of Apocynaceae family

The mechanisms of action of various CGs, particularly the cardenolides present in Apocynaceae plants are discussed in this article, which have the potential to be developed as an alternative or adjunct therapy for the management of heart failure.

Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway

Investigation of the underlying cellular mechanisms of the nitric oxide (NO)-releasing property of AVLE in rat aortas and human umbilical vein endothelial cells (HUVECs) finds it causes endothelium-dependent NO mediated relaxations of rat aorts through Src/PI3K/Akt dependent NO signalling pathway and possesses superoxide scavenging activity.

Protective Effects of Apocynum venetum Against Pirarubicin-Induced Cardiotoxicity.

The study suggests the anti-oxidant and anti-apoptotic properties of AVLE may be responsible for the observed cardioprotective effects of Pirarubicin.

Protective Effects of Caesalpinia sappan Linn. and Its Bioactive Compounds on Cardiovascular Organs

This review aims to provide updates on recent developments in research on C. sappan in relation to treatment of cardiovascular diseases and could help further the understanding of the possible modulatory role of the compounds in cardiovascular diseases, thereby facilitating future studies.

Antioxidant Effects of Apocynum venetum Tea Extracts on d-Galactose-Induced Aging Model in Mice

The results were remarkable, suggesting that AVTE significantly improved d-galactose-induced aging mice, with the high dose group showing the best results among other groups.

Chemopreventive Potential of Ethanolic Extracts of Luobuma Leaves (Apocynum venetum L.) in Androgen Insensitive Prostate Cancer

This study is the first report that lupeol inhibited the expression of UNG to elicit the cytotoxicity against androgen-insensitive-prostate-cancer cells, and holds the potential to be a dietary chemopreventive agent for prostate cancer.

Comparison of the Phenolic Content and Antioxidant Activities of Apocynum venetum L. (Luo-Bu-Ma) and Two of Its Alternative Species

The antioxidant activities of AV were investigated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method, the reducing power test and the chelating ability of ferrous ions.



[Studies on antihypertensive effect of Luobuma (Apocynum venetum L.) leaf extract (3)].

The results suggest that the vasodilation induced by LLE is endothelium-dependent and mediated by endot Helium-derived hyperpolarizing factor, which involves the activation of K(+)-channels.

羅布麻 (紅麻:Apocynum venetum L.) 葉エキスの降圧作用に関する研究(3)

The results suggest that the vasodilation induced by LLE is endothelium-dependent and mediated by endothelia-derived hyperpolarizing factor, which involves the activation of K+-channels, and the higher concentrations of LLE may enhance NO production/release to cause vasodillation.


A novel in vitro vascular relaxant effect of Apocynum venetum leaf extract (AVLE), obtained from a traditional Chinese medicinal herb with known antihypertensive effects, is reported in isometric contraction studies of rat aorta and superior mesenteric artery.

Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.

Human blood platelet 3': 5'-cyclic nucleotide phosphodiesterase. Isolation of low-Km and high-Km phosphodiesterase.

Constituents from leaves of Apocynum venetum L.

Two malonated flavonol glycosides were isolated from Apocynum venetum and showed strong scavenging activity against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and quercetin 3-O-(6′′-O-malonyl)-β-d-galactoside by NMR spectroscopic analysis.

Antidepressant effects of apocynum venetum leaves in a forced swimming test.

The assumption that the antidepressant effect of an Apocynum extract in the FST is specific is confirmed and it can be speculated that this effect might be related to hyperoside and isoquercitrin which are major flavonoids in the extract.

In vitro study on the antioxidant activity of VENETRON, an extract of Apocynum venetum L

  • Igaku Yakugaku
  • 2005