Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

  title={Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.},
  author={Theodore J. Lampidis and Despina Kolonias and Niramol Savaraj and Robert W. Rubin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 4},
Rhythmic, spontaneously pulsating cardiac cells cultured from newborn rats are immediately stimulated to beat faster by addition of a number of tubulin-binding agents but not by their non-tubulin-binding analogues. The tubulin-binding agents tested include vinblastine, vincristine, navelbine, two analogs of vinblastine (S12362 and S12363), nocodazole, colchicine, and podophylotoxin. In addition to binding tubulin, all of the above agents also depolymerize microtubules. In contrast, taxol, a… CONTINUE READING
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