Corpus ID: 22268610

Cardioselective antimuscarinic action of a dopamine receptor agonist, N,N-dipropyl-2-aminotetralin (TL-68).

@article{ahin1987CardioselectiveAA,
  title={Cardioselective antimuscarinic action of a dopamine receptor agonist, N,N-dipropyl-2-aminotetralin (TL-68).},
  author={I. Şahin and M. Ilhan},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1987},
  volume={290 2},
  pages={
          185-92
        }
}
  • I. Şahin, M. Ilhan
  • Published 1987
  • Biology, Medicine
  • Archives internationales de pharmacodynamie et de therapie
  • The antimuscarinic action of N,N-dipropyl-2-amino-tetralin (TL-68) was evaluated using guinea-pig isolated electrically paced left atria, spontaneously beating atria and ileal longitudinal muscle. TL-68 competitively antagonized the responses to carbachol but was less potent than atropine in these preparations. TL-68 exhibits higher affinity towards cardiac muscarinic receptors than ileal receptors and, therefore, possesses cardioselective antimuscarinic properties. TL-68 did not show any… CONTINUE READING