Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

@article{Burns2008CardiorespiratoryFA,
  title={Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.},
  author={Jeffrey M. Burns and Benjamin B Cronk and Heather S. Anderson and Joseph Donnelly and George P. Thomas and A. Harsha and William M. Brooks and Russell Howard Swerdlow},
  journal={Neurology},
  year={2008},
  volume={71 3},
  pages={210-6}
}
OBJECTIVE To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD). BACKGROUND In normal aging physical fitness appears to mitigate functional and structural age-related brain changes. Whether this is observed in AD is not known. METHODS Subjects without dementia (n = 64) and subjects with early-stage AD (n = 57) had MRI and standard clinical and psychometric evaluations. Peak oxygen consumption (VO(2)(peak)), the… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 133 extracted citations

Exercise moderates age-related atrophy of the medial temporal lobe.

Neurobiology of aging • 2011
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Exercise enhances learning and hippocampal neurogenesis in aged mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005

Cardiovascular fitness, cortical plasticity, and aging.

Proceedings of the National Academy of Sciences of the United States of America • 2004

Similar Papers

Loading similar papers…