Corpus ID: 20926290

Cardiorespiratory effects of a 5HT2 antagonist (R51703) in awake and anesthetized dogs.

@article{Doherty1996CardiorespiratoryEO,
  title={Cardiorespiratory effects of a 5HT2 antagonist (R51703) in awake and anesthetized dogs.},
  author={T. Doherty and W. McDonell and D. Dyson and W. Black},
  journal={Canadian journal of veterinary research = Revue canadienne de recherche veterinaire},
  year={1996},
  volume={60 3},
  pages={
          172-8
        }
}
  • T. Doherty, W. McDonell, +1 author W. Black
  • Published 1996
  • Medicine
  • Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
To investigate cardiorespiratory effects of an experimental 5-hydroxytryptamine receptor antagonist (R51703) with sedative properties, intramuscular doses of the drug were studied in 6 awake dogs of mixed breed, and in 6 anesthetized beagles. Two doses (0.2 and 0.4 mg/kg) of R51703 and a saline control were studied in the awake dogs using a randomized crossover trial. Subsequently, the higher dose of R51703 was included as a component of halothane anesthesia to determine whether the halothane… Expand