Cardiorenal syndrome: pathophysiology and potential targets for clinical management

  title={Cardiorenal syndrome: pathophysiology and potential targets for clinical management},
  author={Parta Hatamizadeh and Gregg C Fonarow and Matthew J. Budoff and Sirous Darabian and Csaba Pal Kovesdy and Kamyar Kalantar-Zadeh},
  journal={Nature Reviews Nephrology},
Combined dysfunction of the heart and the kidneys, which can be associated with haemodynamic impairment, is classically referred to as cardiorenal syndrome (CRS). Cardiac pump failure with resulting volume retention by the kidneys, once thought to be the major pathophysiologic mechanism of CRS, is now considered to be only a part of a much more complicated phenomenon. Multiple body systems may contribute to the development of this pathologic constellation in an interconnected network of events… CONTINUE READING
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