Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases.

  title={Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases.},
  author={Cassandra Joffs and Himali R Gunasinghe and Marlina M Multani and Bruce H Dorman and John M. Kratz and Arthur Jackson Crumbley and Fred A. Crawford and Francis G. Spinale},
  journal={The Annals of thoracic surgery},
  volume={71 5},
BACKGROUND A number of cellular and molecular events can be induced after cardiac procedures requiring cardiopulmonary bypass (CPB). The matrix metalloproteinases (MMPs) are a recently discovered family of enzymes that degrade the extracellular matrix, but expression during and after CPB is unknown. METHODS Systemic plasma MMP levels were measured in patients (n = 28, 63 +/- 1 years) undergoing elective coronary revascularization requiring CPB at baseline, termination of CPB, and 30 minutes… CONTINUE READING
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