Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update.

@article{Paparella2002CardiopulmonaryBI,
  title={Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update.},
  author={Domenico Paparella and Terrence M. Yau and Ernest Boyen Young},
  journal={European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
  year={2002},
  volume={21 2},
  pages={
          232-44
        }
}
Cardiac surgery with cardiopulmonary bypass (CPB) induces an acute phase reaction that has been implicated in the pathogenesis of several postoperative complications. Recent data indicate that a complex sequence of events leads to the final activation of leukocytes and endothelial cells (EC), which is responsible for cell dysfunction in different organs. Activation of the contact system, endotoxemia, ischemia and reperfusion injury and surgical trauma are all potential triggers of inflammation… CONTINUE READING
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