Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide.

@article{Matata2000CardiopulmonaryBE,
  title={Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide.},
  author={Bashir Matata and Manuel Gali{\~n}anes},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2000},
  volume={120 1},
  pages={1-11}
}
BACKGROUND Cardiopulmonary bypass induces oxidative stress and a whole-body inflammatory reaction that are believed to increase surgical morbidity. OBJECTIVES Our goal was to investigate the effect of nitric oxide supplementation on bypass-induced oxidative stress and inflammatory reaction in patients with and without diabetes undergoing elective coronary bypass graft surgery. METHODS Patients with and without diabetes were randomized to receive an infusion of saline solution or the nitric… CONTINUE READING
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