Cardiopulmonary bypass and activation of antithrombotic plasma protein C.

  title={Cardiopulmonary bypass and activation of antithrombotic plasma protein C.},
  author={Jari M Pet{\"a}j{\"a} and Ero Pesonen and Jos{\'e} Aneiros Fern{\'a}ndez and Antti Erland Vento and O Juhani R{\"a}m{\"o} and John H. Griffin},
  journal={The Journal of thoracic and cardiovascular surgery},
  volume={118 3},
  pages={422-9; discussion 429-31}
OBJECTIVE We hypothesized that antithrombotic plasma-activated protein C plays a defensive antithrombotic role during coronary ischemia and postischemic reperfusion. METHODS AND RESULTS We evaluated protein C activation during cardiopulmonary bypass and coronary reperfusion in 20 patients undergoing coronary bypass surgery. During cardiopulmonary bypass and during the 10 minutes after aortic unclamping, the plasma levels of protein C (mean +/- standard error of the mean) decreased from 123… CONTINUE READING


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