Cardiopulmonary, histologic, and inflammatory effects of intravenous Na2S after blunt chest trauma-induced lung contusion in mice.

  title={Cardiopulmonary, histologic, and inflammatory effects of intravenous Na2S after blunt chest trauma-induced lung contusion in mice.},
  author={Florian Wagner and Angelika Scheuerle and Sandra Weber and Bettina Stahl and Oscar McCook and Markus W. Kn{\"o}ferl and Markus S Huber-Lang and Daniel H. Seitz and J{\"o}rg Thomas and Pierre Asfar and Csaba Szab{\'o} and Peter M{\"o}ller and Florian Gebhard and Michael K. Georgieff and Enrico Calzia and Peter Radermacher and Katja Wagner},
  journal={The Journal of trauma},
  volume={71 6},
BACKGROUND When used as a pretreatment, hydrogen sulfide (H2S) either attenuated or aggravated lung injury. Therefore, we tested the hypothesis whether posttreatment intravenous Na2S (sulfide) may attenuate lung injury. METHODS After blast wave blunt chest trauma or sham procedure, anesthetized and instrumented mice received continuous intravenous sulfide or vehicle while being kept at 37°C or 32°C core temperature. After 4 hours of pressure-controlled, thoracopulmonary compliance-titrated… 

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