Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected].

@article{Tao2004CardioprotectiveEO,
  title={Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected].},
  author={Ling Jie Tao and E. Mei Gao and Nathan S. Bryan and Yan Qu and Hui-rong Liu and Aihua Hu and Theodore A. Christopher and Bernard L. Lopez and Junji Yodoi and Walter J Koch and Martin Feelisch and Xin L. Ma},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 31},
  pages={11471-6}
}
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) and nitric oxide have been shown to exert antiapoptotic effects in vitro. Recent evidence suggests that this particular action of Trx requires S-nitrosation at Cys-69. The present study sought to investigate whether or not exogenously applied Trx reduces MI/R injury in vivo and to which extent this effect depends on S-nitrosation. Adult mice were subjected to 30 min of MI and treated with either… CONTINUE READING

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