Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion.


OBJECTIVE To investigate the cardioprotective effects of morphine on ischemic reperfused rat heart in vitro and its mechanism. METHODS The isolated rat heart was perfused in a Langendorff apparatus. Infarct myocardium was determined by TTC. Coronary flow (CF), heart rate (HR), left ventricular pressure (LVP), the first derivative of ventricular pressure (LVP/dtmax) and infarct size after ischemia and reperfusion in rat heart given 0.3 micro mol/L morphine were observed. The effects of naloxone and glibenclamide on the cardioprotection of morphine were also measured. RESULTS After ischemia and reperfusion, CF, HR, LVP and LVP/dtmax of isolated rat hearts decreased significantly (P < 0.01). After morphine preconditioning, HR, LVP and LVP/dtmax increased (P < 0.01) and infarct size was reduced significantly (P < 0.01), while no significant change in CF (P > 0.05). The cardioprotective effects of morphine were abolished by naloxone or glibenclamide completely. CONCLUSIONS Morphine can reduce ischemia-reperfusion injuries in isolated rat heart. The cardioprotective effects of morphine are mediated by a local opioid receptor-K(ATP) channel linked mechanism in rat hearts.

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@article{Shi2003CardioprotectiveEO, title={Cardioprotective effects of morphine on rat heart suffering from ischemia and reperfusion.}, author={Enyi Shi and Xiaojing Jiang and Han Bai and Tianxiang Gu and Yetian Chang and Junke Wang}, journal={Chinese medical journal}, year={2003}, volume={116 7}, pages={1059-62} }