Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats

  title={Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats},
  author={Ramin Rezaee and Alireza Sheidary and Saeedeh Jangjoo and Sarvenaz Ekhtiary and Somayeh Bagheri and Zahra Kohkan and Madjid Dadres and Anca Oana Docea and Konstantinos Tsarouhas and Dimosthenis A. Sarigiannis and Spyros P. Karakitsios and Aristidis M. Tsatsakis and Leda Kovatsi and Mahmoud Hashemzaei},
  journal={Drug and Chemical Toxicology},
  pages={668 - 673}
Abstract Carbon monoxide (CO) poisoning causes cardiotoxicity and so far, no definite antidote has been proposed to overcome CO-induced adverse outcomes. Hesperidin, a citrus flavonoid, has shown cardio-protective effects in cardiac ischemia/reperfusion models. This study investigated the protective effects of hesperidin against CO-induced cardiac injury. To induce CO poisoning, rats were exposed to CO at 3000 ppm for 60 min. On the exposure day and the four following days, hesperidin (at three… 

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Carbon monoxide poisoning



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