Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.

@article{Patel2012CardioprotectiveEM,
  title={Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice.},
  author={Vaibhav B. Patel and Sreedhar Bodiga and Dong Fan and Subhash K. Das and Zuocheng Wang and Wang Wang and Ratnadeep Basu and Jiuchang Zhong and Zamaneh Kassiri and Gavin Yadram Oudit},
  journal={Hypertension},
  year={2012},
  volume={59 6},
  pages={1195-203}
}
Loss of angiotensin (Ang)-converting enzyme 2 (ACE2) and inability to metabolize Ang II to Ang 1-7 perpetuate the actions of Ang II after biomechanical stress and exacerbate early adverse myocardial remodeling. Ang receptor blockers are known to antagonize the effect of Ang II by blocking Ang II type 1 receptor (AT(1)R) and also by upregulating the ACE2 expression. We directly compare the benefits of AT(1)R blockade versus enhancing Ang 1-7 action in pressure-overload-induced heart failure in… CONTINUE READING