Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats.

@article{Senthil2007CardioprotectiveEO,
  title={Cardioprotective effect of oleanolic acid on isoproterenol-induced myocardial ischemia in rats.},
  author={S Lakshmana Senthil and Muruhan Sridevi and Kodukkur Viswanathan Pugalendi},
  journal={Toxicologic pathology},
  year={2007},
  volume={35 3},
  pages={418-23}
}
This study was designed to investigate the protective effect of oleanolic acid (OA) against isoproterenol-induced myocardial ischemia in rat myocardium. Wistar strain rats were pretreated with OA (20, 40, and 60 mg/kg, s.c) for 7 days and then intoxicated with isoproterenol (ISO, 85 mg/kg, sc for 2 consecutive days). Heart were excised from the experimental animals and assessed for the activities of marker enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate… CONTINUE READING