Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity.

  title={Cardioprotective effect of cannabidiol in rats exposed to doxorubicin toxicity.},
  author={Amr A. Fouad and Waleed H Albuali and Abdulruhman S Al-Mulhim and Iyad Jresat},
  journal={Environmental toxicology and pharmacology},
  volume={36 2},

Pentoxifylline abrogates cardiotoxicity induced by the administration of a single high dose or multiple low doses of doxorubicin in rats.

The results warrant the clinical use of PXF as an adjuvant therapy to abrogate cardiotoxicity of DOX and extend its clinical applications.

The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice

Cardenolide glycoside A might act as a cardioprotective agent to prevent doxorubicin-induced cardiotoxicity as indicated by normalization of the levels of different myocardial markers of oxidative stress, serum myocardIAL diagnostic marker enzymes, and inflammatory markers.

The Role of Flavonoids as a Cardioprotective Strategy against Doxorubicin-Induced Cardiotoxicity: A Review

This review comprehensively summarizes cardioprotective activity flavonoids including quercetin, luteolin, rutin, apigenin, naringenin, and hesperidin against doxorubicin, both in in vitro and in vivo models.

Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat

Pretreatment with diazoxide attenuates doxorubicin-induced cardiac dysfunction in the rat, measured by physiological indices and TnT and H2O2 in effluate from isolated hearts, and could be mediated by opening of mitochondrial KATP-channels, reduced dox orubic in-associated free radical generation and decreased cardiomyocyte damage.

Effect of Urtica Dioica against Doxorubicin-InducedCardiotoxicity in Rats through Suppression ofHistological Damage, Oxidative Stress and LipidPeroxidation

UD therapy significantly protected against DOXinduced myocardial damage which was characterized by conduction abnormalities, vacuolization, inflammatory cell infiltration, hemorrhag es, and myofibrillar disarrangement.

Pristimerin protects against doxorubicin-induced cardiotoxicity and fibrosis through modulation of Nrf2 and MAPK/NF-kB signaling pathways

Evidence is provided of the cardioprotective activity of Pris which is related to the modulation of Nrf2 and MAPK/NF-kB signaling pathways and its effect on doxorubicin (DOX)-induced cardiotoxic effects.

Cardioprotective Effect of Ajwa Date Aqueous Extract on Doxorubicin-Induced Toxicity in Rats

It can be concluded that Ajwa date offers a considerable protection against DOX-induced cardiotoxicity in rats and enhanced DNA integrity.

Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity

  • H. AşçiO. Ozmen N. Hasseyid
  • Medicine, Biology
    Biotechnic & histochemistry : official publication of the Biological Stain Commission
  • 2020
Immunohistochemical evaluation of the heart and aorta revealed a significant increase in the levels of Cas-3, G-CSF, SAA, IL-6 and iNOS in the LPS group, which indicated LPS induced cardiovascular toxicity was due to inflammation, oxidative stress and apoptosis.



Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats.

The results suggest that Def might be a potential cardioprotective agent against Dox-induced cardiotoxicity, and significantly attenuated the biochemical changes.

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

Treatment of mice with cannabidiol markedly attenuated the cisplatin-induced oxidative/nitrosative stress, inflammation, and cell death in the kidney, and it improved renal function, suggesting that cannABidiol may represent a promising new protective strategy against cisplarin-induced nephrotoxicity.

Salvianolic acids prevent acute doxorubicin cardiotoxicity in mice through suppression of oxidative stress.

  • B. JiangLin Zhang D. Guo
  • Chemistry, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008

Electrocardiographic and biochemical evidence for the cardioprotective effect of antioxidants in acute doxorubicin-induced cardiotoxicity in the beagle dogs.

Doxorubicin (DOX) is a potent antitumor agent, but the cardiotoxicity mediated by the formation of reactive oxygen species limit its clinical use. The present study aims to explore

Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury.

Cannabidiol induces a substantial in vivo cardioprotective effect from ischemia that is not observed ex vivo, and may represent a promising novel treatment for myocardial ischemIA.

Interrelations between oxidative stress and calcineurin in the attenuation of cardiac apoptosis by eugenol

The beneficial effects of eugenol are indicated in preventing cardiomyocyte apoptosis in neonatalCardiomyocytes by reversal of enhanced intracellular Ca2+ levels, oxidative stress, calcineurin activation and apoptosis caused by isoproterenol.

Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw

Oral cannabidiol has a beneficial action on two symptoms of established inflammation: edema and hyperalgesia and the effect on NO seemed to depend on a lower expression of the endothelial isoform of NO synthase.