Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase.

  title={Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase.},
  author={Xiaolin Niu and Vabren L Watts and Oscar H. Cingolani and Vidhya Sivakumaran and Jordan S. Leyton-Mange and Carla L Ellis and Karen L. Miller and Konrad M Vandegaer and Djahida Bedja and Kathleen L. Gabrielson and Nazareno Paolocci and David A. Kass and Lili A. Barouch},
  journal={Journal of the American College of Cardiology},
  volume={59 22},
OBJECTIVES The aim of this study was to determine whether activation of β3-adrenergic receptor (AR) and downstream signaling of nitric oxide synthase (NOS) isoforms protects the heart from failure and hypertrophy induced by pressure overload. BACKGROUND β3-AR and its downstream signaling pathways are recognized as novel modulators of heart function. Unlike β1- and β2-ARs, β3-ARs are stimulated at high catecholamine concentrations and induce negative inotropic effects, serving as a "brake" to… CONTINUE READING
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