Cardioprotective effect of adrenomedullin in heart failure.

  title={Cardioprotective effect of adrenomedullin in heart failure.},
  author={Toshio Nishikimi and Fumiki Yoshihara and Yosuke Mori and Kenji Kangawa and Hiroaki Matsuoka},
  journal={Hypertension research : official journal of the Japanese Society of Hypertension},
  volume={26 Suppl},
Many neurohumoral factors participate in the pathophysiology of heart failure, and adrenomedullin (AM) may be involved in their derangement. This work reviews the accumulating evidence in support of a compensatory role of AM in heart failure, and describes the possible mechanisms of this role. It has been established that plasma AM levels are increased in patients with heart failure in proportion to the severity of the disease. Furthermore, recent studies suggest that plasma AM level is an… CONTINUE READING


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