Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.

@article{Zabielska2018CardioprotectiveEO,
  title={Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.},
  author={M. Zabielska and J. Adamus and R. Kowalski and J. Gȩbicki and E. Słomińska and Z. Khalpey and R. Smolenski},
  journal={Pharmacological reports : PR},
  year={2018},
  volume={70 2},
  pages={
          378-384
        }
}
  • M. Zabielska, J. Adamus, +4 authors R. Smolenski
  • Published 2018
  • Medicine
  • Pharmacological reports : PR
  • BACKGROUND Pyruvate improves contractility of normal, hypoxic, and post-ischemic myocardium. However, sodium overload is a major problem with its therapeutic application if sodium pyruvate is used. Development of alternative forms such as N-1-methylnicotinamide (MNA) pyruvate may help to overcome this problem. The aim of the study was to investigate the effect of MNA pyruvate in a murine model of cardiac ischemia. METHODS Seven month old male ApoE-/-LDLr-/- mice that develop myocardial… CONTINUE READING

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