Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.

@article{Wang2010CardioprotectiveAA,
  title={Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart.},
  author={Guangwu Wang and Tariq Parwaiz Hamid and Rachel J Keith and Guihua Zhou and Charles R. Partridge and Xilin Xiang and Justin R Kingery and Robert K Lewis and Qianhong Li and D. Gregg Rokosh and Rachael Ford and Francis G. Spinale and Daniel W. Riggs and Sanjay Mohan Srivastava and Aruni Bhatnagar and Roberto Bolli and Sumanth D. Prabhu},
  journal={Circulation},
  year={2010},
  volume={121 17},
  pages={1912-25}
}
BACKGROUND Heme oxygenase-1 (HO-1) is an inducible stress-response protein that imparts antioxidant and antiapoptotic effects. However, its pathophysiological role in cardiac remodeling and chronic heart failure (HF) is unknown. We hypothesized that induction of HO-1 in HF alleviates pathological remodeling. METHODS AND RESULTS Adult male nontransgenic and myocyte-restricted HO-1 transgenic mice underwent either sham operation or coronary ligation to induce HF. Four weeks after ligation… CONTINUE READING