Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).

  title={Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).},
  author={Sylvia Pietri and Eziana Maurelli and Katy Drieu and Marcel Culcasi},
  journal={Journal of molecular and cellular cardiology},
  volume={29 2},
Hemodynamic and electron spin resonance analyses were used to assess the in vivo and in vitro cardioprotective and antioxidant effects of therapeutically relevant doses of Ginkgo biloba extract (EGb 761) and its terpenoid constituents (ginkgolides A and B, bilobalide) in the rat. Significant anti-ischemic effects, indicating improved myocardial functional recovery, were observed after repeated (15-day) oral treatments with both EGb 761 (60 mg/kg/day) and ginkgolide A (4 mg/kg/day), as compared… 
Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion
Findings provide the first evidence that part of the cardioprotection afforded by EGb 761 is due to a specific action of its terpenoid constituents and that this effect involves a mechanism independent of direct free radical-scavenging.
Cardioprotective effect of a chronic treatment of Ginkgo biloba Phytosomes in isoproterenol-induced cardiac necrosis in rats : Involvement of antioxidant system
The present study investigates the cardioprotective effect and antioxidant activity of a chronic treatment of Ginkgo biloba Phytosomes (GBP) in isoproterenol (ISO) induced cardiac necrosis in rats.
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.
  • Vandana Panda, S. Naik
  • Chemistry, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2008
The present findings have demonstrated that the cardioprotective effects of GBP in ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation of membrane.
Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia
Oral administration of bilobalide and EGb 761 protect against ischemia-induced neuron death and reductions in mitochondrial gene expression, which are suggested to be important for neuroprotective effects against ischemic injury.
Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin‐induced cardiac injury in rats
GSPE and EGb761 mediate their protective effect against DOX‐induced cardiac injury through antioxidant, anti‐inflammatory and antiapoptotic mechanisms.
Evaluation of cardioprotective activity of Ginkgo biloba and Ocimum sanctum in rodents.
  • Vandana Panda, S. N
  • Medicine, Chemistry
    Alternative medicine review : a journal of clinical therapeutic
  • 2009
It may be concluded that GBP-Os oral treatment to ISO-challenged rats demonstrates significant cardiac protection, decreases lipid peroxidation, and restores antioxidant activities.
Effect of the extract of Ginkgo biloba (EGb 761) on the circulating and cellular profiles of polyunsaturated fatty acids: correlation with the anti-oxidant properties of the extract.
Considering that PUFAs are known to improve membrane fluidity and response to oxidative damage, the effects of EGb 761 on circulating and cellularPUFAs may explain some of the pharmacological properties of Ginkgo biloba.
Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway
The data support the notion that antihypertrophic effect of GBE occurs via activation of M2/NO pathway uncovering a new mechanism involved in the cardioprotective action of Ginkgo biloba.
Anti-ischaemic effects of bilobalide on neonatal rat cardiomyocytes and the involvement of the platelet-activating factor receptor
Results indicate that PAF and its receptor may be involved in the cellular response of cardiomyocytes to hypoxia and that bilobalide may interact with this receptor to exert its cardioprotective effects.
Synthesis and biological studies of a new ginkgolide C derivative: Evidence that the cardioprotective effect of ginkgolides is unrelated to PAF inhibition
The data provide additional support to a PAF‐unrelated pharmacological activity for ginkgolides, and suggest its increased affinity for the myocardium, as compared to the relatively more hydrophilic 3.


Reperfusion injury and its pharmacologic modification.
From the therapeutic point of view, the divergent results of experimental interventions and the possibility that the abrupt onset of reperfusion in animals differs from the situation in humans with thrombolysis means that the best way currently available to limit reperFusion injury is by minimizing the ischemic period by early reperfusions and by optimizing the metabolic status of the isChemic myocardium at the end of theIschemicperiod.
The specificity of proanthocyanidin-protein interactions.
The specificity of the interaction was investigated using a competitive binding assay to compare directly the affinities of various proteins and synthetic polymers for the tannin obtained from Sorghum bicolor (Lin.) Moench, indicating that this proanthocyanidin interacts quite selectively with protein and protein-like polymers.