Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).

@article{Pietri1997CardioprotectiveAA,
  title={Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).},
  author={Sylvia Pietri and Eziana Maurelli and Katy Drieu and Marcel Culcasi},
  journal={Journal of molecular and cellular cardiology},
  year={1997},
  volume={29 2},
  pages={
          733-42
        }
}
Hemodynamic and electron spin resonance analyses were used to assess the in vivo and in vitro cardioprotective and antioxidant effects of therapeutically relevant doses of Ginkgo biloba extract (EGb 761) and its terpenoid constituents (ginkgolides A and B, bilobalide) in the rat. Significant anti-ischemic effects, indicating improved myocardial functional recovery, were observed after repeated (15-day) oral treatments with both EGb 761 (60 mg/kg/day) and ginkgolide A (4 mg/kg/day), as compared… 
Complementary cardioprotective effects of flavonoid metabolites and terpenoid constituents of Ginkgo biloba extract (EGb 761) during ischemia and reperfusion
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Findings provide the first evidence that part of the cardioprotection afforded by EGb 761 is due to a specific action of its terpenoid constituents and that this effect involves a mechanism independent of direct free radical-scavenging.
Cardioprotective effect of a chronic treatment of Ginkgo biloba Phytosomes in isoproterenol-induced cardiac necrosis in rats : Involvement of antioxidant system
The present study investigates the cardioprotective effect and antioxidant activity of a chronic treatment of Ginkgo biloba Phytosomes (GBP) in isoproterenol (ISO) induced cardiac necrosis in rats.
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.
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  • Medicine, Chemistry
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  • 2009
TLDR
It may be concluded that GBP-Os oral treatment to ISO-challenged rats demonstrates significant cardiac protection, decreases lipid peroxidation, and restores antioxidant activities.
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TLDR
Considering that PUFAs are known to improve membrane fluidity and response to oxidative damage, the effects of EGb 761 on circulating and cellularPUFAs may explain some of the pharmacological properties of Ginkgo biloba.
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Results indicate that PAF and its receptor may be involved in the cellular response of cardiomyocytes to hypoxia and that bilobalide may interact with this receptor to exert its cardioprotective effects.
Synthesis and biological studies of a new ginkgolide C derivative: Evidence that the cardioprotective effect of ginkgolides is unrelated to PAF inhibition
TLDR
The data provide additional support to a PAF‐unrelated pharmacological activity for ginkgolides, and suggest its increased affinity for the myocardium, as compared to the relatively more hydrophilic 3.
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