Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors

@article{Packer2020CardioprotectiveEO,
  title={Cardioprotective Effects of Sirtuin-1 and Its Downstream Effectors},
  author={Milton Packer},
  journal={Circulation: Heart Failure},
  year={2020},
  volume={13},
  pages={e007197}
}
  • M. Packer
  • Published 1 September 2020
  • Biology
  • Circulation: Heart Failure
The cardioprotective effects of SGLT2 (sodium-glucose cotransporter 2) inhibitors may be related to their ability to induce a fasting-like paradigm, which triggers the activation of nutrient deprivation pathways to promote cellular homeostasis. The most distinctive metabolic manifestations of this fasting mimicry are enhanced gluconeogenesis and ketogenesis, which are not seen with other antihyperglycemic drugs. The principal molecular stimulus to gluconeogenesis and ketogenesis is activation… 

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