Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase

  title={Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase},
  author={Seok Kyu Oh and Kyeong Ho Yun and Nam-Jin Yoo and Nam Ho Kim and Min-Sun Kim and Byung Rim Park and Jin Won Jeong},
  journal={Korean Circulation Journal},
  pages={359 - 366}
  • S. OhK. Yun J. Jeong
  • Published 1 September 2009
  • Medicine, Biology
  • Korean Circulation Journal
Background and Objectives Reactive oxygen species (ROS) and mitogen-activated protein (MAP) kinase play an important role in the development of myocardial reperfusion injury. In this study, we examined whether treatment with alpha-lipoic acid (ALA) before reperfusion could prevent myocardial reperfusion injury in vivo. Materials and Methods Sprague-Dawley rats were subjected to a 45-minute left anterior descending coronary artery ligation followed by 45- or 10-minute reperfusion. ALA was… 

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