Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase
@article{Oh2009CardioprotectiveEO, title={Cardioprotective Effects of Alpha-Lipoic Acid on Myocardial Reperfusion Injury: Suppression of Reactive Oxygen Species Generation and Activation of Mitogen-Activated Protein Kinase}, author={Seok Kyu Oh and Kyeong Ho Yun and Nam-Jin Yoo and Nam Ho Kim and Min-Sun Kim and Byung Rim Park and Jin Won Jeong}, journal={Korean Circulation Journal}, year={2009}, volume={39}, pages={359 - 366} }
Background and Objectives Reactive oxygen species (ROS) and mitogen-activated protein (MAP) kinase play an important role in the development of myocardial reperfusion injury. In this study, we examined whether treatment with alpha-lipoic acid (ALA) before reperfusion could prevent myocardial reperfusion injury in vivo. Materials and Methods Sprague-Dawley rats were subjected to a 45-minute left anterior descending coronary artery ligation followed by 45- or 10-minute reperfusion. ALA was…
18 Citations
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