Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model

  title={Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model},
  author={Adam Riba and Laszlo Deres and Bal{\'a}zs Sumegi and Kalman Toth and Eszter Szabados and R{\'o}bert Halmosi},
  journal={Oxidative Medicine and Cellular Longevity},
Despite great advances in therapies observed during the last decades, heart failure (HF) remained a major health problem in western countries. In order to further improve symptoms and survival in patients with heart failure, novel therapeutic strategies are needed. In some animal models of HF resveratrol (RES), it was able to prevent cardiac hypertrophy, contractile dysfunction, and remodeling. Several molecular mechanisms are thought to be involved in its protective effects, such as inhibition… 

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Therapeutic potential of resveratrol in heart failure

  • M. SungJ. Dyck
  • Biology, Medicine
    Annals of the New York Academy of Sciences
  • 2015
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Resveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR and may have potential in preventing cardiac impairment in patients with essential hypertension.

Protective effect of resveratrol against pressure overload-induced heart failure

Resveratrol treatment significantly attenuates the adverse cardiac remodeling and dysfunction produced by the TAC protocol in C57/BL6 mice and this activity is mediated, at least in part, by the inhibition of oxidative stress and inflammation indicating a therapeutic potential of resveratro in HF.

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Combinational effect of resveratrol and atorvastatin on isoproterenol-induced cardiac hypertrophy in rats

It can be concluded that resveratrol, an herbal nutritional supplement, alone and in combination is better against cardiac hypertrophy.

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Results suggest that KR-33889 may have therapeutic potential to prevent I/R-induced heart injury in ischemic heart diseases mainly by reducing oxidative stress-mediated myocardial apoptosis.

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