Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model
@article{Riba2017CardioprotectiveEO, title={Cardioprotective Effect of Resveratrol in a Postinfarction Heart Failure Model}, author={Adam Riba and Laszlo Deres and Bal{\'a}zs Sumegi and Kalman Toth and Eszter Szabados and R{\'o}bert Halmosi}, journal={Oxidative Medicine and Cellular Longevity}, year={2017}, volume={2017} }
Despite great advances in therapies observed during the last decades, heart failure (HF) remained a major health problem in western countries. In order to further improve symptoms and survival in patients with heart failure, novel therapeutic strategies are needed. In some animal models of HF resveratrol (RES), it was able to prevent cardiac hypertrophy, contractile dysfunction, and remodeling. Several molecular mechanisms are thought to be involved in its protective effects, such as inhibition…
Figures and Tables from this paper
83 Citations
Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction
- Biology, MedicineFrontiers in Pharmacology
- 2021
It is suggested that RES exerts a protective action against HFpEF-induced adverse cardiac remodeling by decreasing Smad3 acetylation and transcriptional activity via activating Sirt1.
Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
- Biology, MedicineInternational journal of molecular sciences
- 2021
The major mechanisms by which polyphenols mitigate HF in vitro and in vivo are discussed, including reduced cardiac inflammation and oxidative stress, reduced mitochondrial dysfunction, improved Ca2+ homeostasis, increased survival signaling, and increased sirtuin 1 activity.
Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms
- BiologyOxidative medicine and cellular longevity
- 2020
The roles of RSV are discussed by focusing its downstream targets from both in vivo and in vitro studies by identifying Sirtuins 1/3 and AMP-activated kinase as key mediators that induce cardioprotection during hyperglycemia.
Resveratrol Improves Heart Function by Moderating Inflammatory Processes in Patients with Systolic Heart Failure
- Medicine, BiologyAntioxidants
- 2020
The main findings of this trial are that RES treatment added to the standard heart failure therapy improved heart function and the clinical condition by moderating the inflammatory processes in patients with HFrEF.
Cardioprotective Effects of Dietary Phytochemicals on Oxidative Stress in Heart Failure by a Sex-Gender-Oriented Point of View
- BiologyOxidative medicine and cellular longevity
- 2020
The aim of this review is to summarize the possible role of dietary phytochemicals in HF therapy and the evidence of a different sex-gender-oriented response.
The Potential Properties of Natural Compounds in Cardiac Stem Cell Activation: Their Role in Myocardial Regeneration
- Medicine, BiologyNutrients
- 2021
The present review will summarize the recent advances in knowledge of stem cell therapy in the management of CVDs; focusing on the main properties and potential mechanisms of natural compounds in stimulating and activating stem cells for myocardial regeneration.
Imine stilbene analog ameliorate isoproterenol-induced cardiac hypertrophy and hydrogen peroxide-induced apoptosis.
- BiologyFree radical biology & medicine
- 2020
Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations
- BiologyOxidative medicine and cellular longevity
- 2022
The findings confirmed that resveratrol has cardioprotective effects at several points by counteracting the aging-associated cellular malfunctions in the heart.
Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats
- Biology, MedicineMolecules
- 2021
Resveratrol, sacubitril/valsartan, and valsartan significantly prevented cardiac remodeling and dysfunction in MI-induced rats and significantly reduced myocardial tissue oxidative stress, inflammation and fibrosis.
Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease
- Biology, MedicineDrug design, development and therapy
- 2019
The results indicate that the aberrations in cardiac function and aortic elastin morphology observed in the 3xTg mouse model of AD can be prevented with exercise training and treatment with resveratrol.
References
SHOWING 1-10 OF 57 REFERENCES
Therapeutic potential of resveratrol in heart failure
- Biology, MedicineAnnals of the New York Academy of Sciences
- 2015
As heart failure induces alterations in skeletal muscle and vasculature that also contribute to certain heart failure symptoms, such as fatigue and exercise intolerance, it has been shown that resveratrol acts on these peripheral tissues to improve skeletal Muscle and endothelial/vascular function.
Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway.
- Biology, ChemistryThe American journal of pathology
- 2013
Resveratrol prevents the development of pathological cardiac hypertrophy and contractile dysfunction in the SHR without lowering blood pressure.
- Medicine, BiologyAmerican journal of hypertension
- 2010
Resveratrol treatment was beneficial in preventing the development of concentric hypertrophy and cardiac dysfunction in SHR and may have potential in preventing cardiac impairment in patients with essential hypertension.
Protective effect of resveratrol against pressure overload-induced heart failure
- BiologyFood science & nutrition
- 2014
Resveratrol treatment significantly attenuates the adverse cardiac remodeling and dysfunction produced by the TAC protocol in C57/BL6 mice and this activity is mediated, at least in part, by the inhibition of oxidative stress and inflammation indicating a therapeutic potential of resveratro in HF.
Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats.
- Biology, MedicineCirculation research
- 1994
It is demonstrated that diffuse isoproterenol-induced myocardial necrosis results in a progressive enlargement of the LV cavity that is out of proportion to mass, a finding similar to that observed in discrete myocardIAL infarction.
Combinational effect of resveratrol and atorvastatin on isoproterenol-induced cardiac hypertrophy in rats
- Biology, ChemistryJournal of pharmacy & bioallied sciences
- 2015
It can be concluded that resveratrol, an herbal nutritional supplement, alone and in combination is better against cardiac hypertrophy.
Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway.
- Biology, ChemistryFree radical biology & medicine
- 2009
Cardioprotective effect of KR-33889, a novel PARP inhibitor, against oxidative stress-induced apoptosis in H9c2 cells and isolated rat hearts
- Biology, ChemistryArchives of pharmacal research
- 2017
Results suggest that KR-33889 may have therapeutic potential to prevent I/R-induced heart injury in ischemic heart diseases mainly by reducing oxidative stress-mediated myocardial apoptosis.
COX-2 and Atherosclerosis
- BiologyJournal of cardiovascular pharmacology
- 2006
Findings from the group suggesting a crucial role for COX-2 in modulating atherosclerotic plaque stability or instability are summarized, according to the variable expression of upstream and downstream enzymes in the prostanoid biosynthesis.