Cardioprotective Actions by a Water‐Soluble Carbon nMonoxide‐Releasing Molecule

@article{Clark2003CardioprotectiveAB,
  title={Cardioprotective Actions by a Water‐Soluble Carbon nMonoxide‐Releasing Molecule},
  author={James E. Clark and P. Naughton and S. Shurey and C. Green and T. Johnson and B. Mann and R. Foresti and R. Motterlini},
  journal={Circulation Research},
  year={2003},
  volume={93},
  pages={1–7}
}
&NA; Carbon monoxide, which is generated in mammals during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator. Transition metal carbonyls have been recently shown to function as carbon monoxide‐releasing molecules (CO‐RMs) and to elicit distinct pharmacological activities in biological systems. In the present study, we report that a water‐soluble form of CO‐RM promotes cardioprotection in vitro and in vivo. Specifically, we found that tricarbonylchloro… Expand
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