Cardioprotection with the KATP opener cromakalim is not correlated with ischemic myocardial action potential duration.

@article{Grover1995CardioprotectionWT,
  title={Cardioprotection with the KATP opener cromakalim is not correlated with ischemic myocardial action potential duration.},
  author={Gary James Grover and Albert J. D'Alonzo and Charles S. Parham and Raymond B. Darbenzio},
  journal={Journal of cardiovascular pharmacology},
  year={1995},
  volume={26 1},
  pages={145-52}
}
We endeavored to determine if the enhanced shortening of the myocardial action potential duration (APD) during ischemia can be dissociated from the cardioprotective effects of the adenosine triphosphate (ATP) sensitive potassium channel (KATP) opener cromakalim. To establish if there is a relationship between APD shortening and the cardioprotective effect of cromakalim, we determined the effect of a dose of the delayed rectifier (IKr) blocker dofetilide (which abolishes the APD shortening… CONTINUE READING

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