Cardioprotection with Alcohol

  title={Cardioprotection with Alcohol},
  author={Motoaki Sato and Nilanjana Maulik and Dipak Kumar Das},
  journal={Annals of the New York Academy of Sciences},
Abstract: Both epidemiological and experimental studies indicate that mild‐to‐moderate alcohol consumption is associated with a reduced incidence of mortality and morbidity from coronary heart disease. The consumption of wine, particularly red wine, imparts a greater benefit in the prevention of coronary heart disease than the consumption of other alcoholic beverages. The cardioprotective effects of red wine have been attributed to several polyphenolic antioxidants including resveratrol and… 

Cardiovascular protection from alcoholic drinks: scientific basis of the French Paradox.

  • R. Providência
  • Medicine
    Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology
  • 2006
The cardiovascular protection afforded by low to moderate consumption of ethanol and the role of ethanol-induced preconditioning are discussed and clinical applications and possibilities raised by these new findings are focused on.

Ethanol, wine, and experimental cardioprotection in ischemia/reperfusion: role of the prooxidant/antioxidant balance.

Experimental evidence suggests that ethanol and/or nonethanolic components of wine might exert preconditioning effects in animal models of myocardial ischemia/reperfusion, and such an observation, if confirmed in human subjects, might open new perspectives in the prevention and treatment of ischemic coronary heart disease.

Antioxidant Effects and Drug Interactions of Resveratrol Present in Wine

Results indicate that resveratrol has higher antioxidant effects than vitamin E and should be used with caution while other drugs are taken.

Intake of fermented beverages protect against acute myocardial injury: target organ cardiac effects and vasculoprotective effects

Overall cardiac performance was improved in beer-fed animals regardless of the dose or alcohol content, and beer intake reduces oxidative stress and apoptosis, activates RISK components and favors reparative fibrosis improving global cardiac performance.

The Sirtuin System: The Holy Grail of Resveratrol?

It is resolved that while early data on Resveratrol are promising, the anti-oxidative and ultimately, anti-atherosclerotic potential depends on further clarification of the intricate and complex relationship between Resver atrol and the Sirtruin system.

Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis

Administration of low doses of red wine can attenuate the proatherogenic effects induced by perturbed shear stress in vitro and in vivo, which may have implications for the prevention of atherosclerotic lesion progression and its clinical manifestations.

The red wine hypothesis: from concepts to protective signalling molecules.

Evidence for and against the 'red wine hypothesis', whereby red wine is more likely to confer cardiovascular benefits than white wine are reviewed, and Mechanistic feasibility strengthens the case for prospective therapeutic trials of alcohol vs. red wine vs. resveratrol.

Resveratrol and anti-atherogenic effects

Resveratrol is believed to decrease circulating low-density lipoprotein cholesterol levels, reduce cardiovascular disease risk; it reduces lipid peroxidation, platelet aggregation and oxidative stress.

Resveratrol in cardiovascular health and disease

The successful application of resveratrol in therapy is based upon its hormetic action similar to any toxin: exerting beneficial effects at lower doses and cytotoxic effects at higher doses.

Alcohol and cardiovascular disease: possible protection via effects on aortic stiffness.

Beneficial effects of regular alcohol drinking on insulin sensitivity and the risk of diabetes have also been reported in some population studies, although obesity is a strong confounder, and the effects on glucose tolerance could not be confirmed in a randomized controlled trial involving a reduction of alcohol consumption in regular drinkers.



Cardioprotective effects of grape seed proanthocyanidin against ischemic reperfusion injury.

The results of this study demonstrated that proanthocyanidin-fed animals were resistant to myocardial ischemia reperfusion injury as evidenced by improved recovery of post-ischemic contractile functions.

Myocardial protection with red wine extract.

The results of this study demonstrated that both red wine extract and RVT were equally cardioprotective, as evidenced by their abilities to improve postischemic ventricular functions including developed pressure and aortic flow.

Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts.

Grape seed proanthocyanidins have cardioprotective effects against reperfusion-induced injury via their ability to reduce or remove, directly or indirectly, free radicals in myocardium that is reperfused after ischemia.

Alcohol and coronary heart disease: the evidence for a protective effect.

  • W. KannelR. Ellison
  • Medicine
    Clinica chimica acta; international journal of clinical chemistry
  • 1996
No alternative explanation for the protective effect has surfaced after two decades of investigation of the alcohol-CHD relationship, yet, the penalties of heavy alcohol consumption are too large to ignore.

Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation.

The antioxidant effect of dietary red wine on plasma lipid peroxidation was not secondary to changes in the plasma vitamin E or beta-carotene content but could be related to the elevation of polyphenol concentration in plasma and LDL.