Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury.

@article{Tanajak2018CardioprotectionOD,
  title={Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury.},
  author={Pongpan Tanajak and Piangkwan Sa-nguanmoo and Sivaporn Sivasinprasasn and Savitree Thummasorn and Natthaphat Siri-Angkul and Siriporn C Chattipakorn and Nipon Chattipakorn},
  journal={The Journal of endocrinology},
  year={2018},
  volume={236 2},
  pages={
          69-84
        }
}
Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion (I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have shown effective cardioprotection in cardiac I/R injury. We aimed to investigate whether SGLT2-i reduces myocardial dysfunction and myocardial injury to a greater extent than DPP4-i in obese insulin-resistant rats with/without cardiac I/R injury. The high-fat (HF) diet-induced obese insulin-resistant rats were divided… CONTINUE READING

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