Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway.

  title={Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway.},
  author={Narasimman Gurusamy and Istvan Lekli and Subhendu Mukherjee and Diptarka Ray and Md Kaimul Ahsan and Mihaela Gherghiceanu and Lawrence M Popescu and Dipak Kumar Das},
  journal={Cardiovascular research},
  volume={86 1},
AIMS On the basis of our previous reports that cardioprotection induced by ischaemic preconditioning induces autophagy and that resveratrol, a polyphenolic antioxidant present in grapes and red wine induces preconditioning-like effects, we sought to determine if resveratrol could induce autophagy. METHODS AND RESULTS Resveratrol at lower doses (0.1 and 1 microM in H9c2 cardiac myoblast cells and 2.5 mg/kg/day in rats) induced cardiac autophagy shown by enhanced formation of autophagosomes and… CONTINUE READING
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