Cardioprotection by orotic acid: metabolism and mechanism of action.

  title={Cardioprotection by orotic acid: metabolism and mechanism of action.},
  author={S. Richards and R. Conyers and J. L. Fisher and F. Rosenfeldt},
  journal={Journal of molecular and cellular cardiology},
  volume={29 12},
The pyrimidine base, orotic acid (OA), improves the function of recently infarcted hearts subjected to global ischemia but its mechanism of action is unclear. Our aims were to examine (i) in normal rats, the effect of OA on pyrimidine levels in plasma, liver and heart; (ii) in rats with normal or infarcted hearts, the effect of OA on adenine nucleotide metabolism and mechanical function, before and after global ischemia. To investigate the metabolism of OA, normal rats received 100 mg/kg OA… Expand
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