Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia.

@article{LaDisa2004CardioprotectionBG,
  title={Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia.},
  author={John F. LaDisa and John G. Krolikowski and Paul S. Pagel and David C. Warltier and Judy R. Kersten},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={287 2},
  pages={
          H601-7
        }
}
We tested the hypothesis that glucose-insulin-potassium (GIK)-induced protection against myocardial infarction depends on ATP-dependent K(+) (K(ATP)) channel activation and is abolished by hyperglycemia before the ischemia. Dogs were subjected to a 60-min coronary artery occlusion and 3-h reperfusion in the absence or presence of GIK (25% dextrose; 50 IU insulin/l; 80 mM/l KCl infused at 1.5 ml x kg(-1) x h(-1)) beginning 75 min before coronary artery occlusion or 5 min before reperfusion. The… CONTINUE READING

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