Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction.

@article{Mohan2009CardioprotectionBH,
  title={Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction.},
  author={Iyyapu Krishna Mohan and Mahmood Khan and Sheik Wisel and Karuppaiyah Selvendiran and Arun Raghav Mahankali Sridhar and Cynthia A. Carnes and Bal{\'a}zs Bogn{\'a}r and T{\'a}m{\'a}s K{\'a}l{\'a}i and K{\'a}lm{\'a}n Hideg and Periannan Kuppusamy},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 1},
  pages={
          H140-51
        }
}
Many cardiac interventional procedures, such as coronary angioplasty, stenting, and thrombolysis, attempt to reintroduce blood flow (reperfusion) to an ischemic region of myocardium. However, the reperfusion is accompanied by a complex cascade of cellular and molecular events resulting in oxidative damage, termed myocardial ischemia-reperfusion (I/R) injury. In this study, we evaluated the ability of HO-4038, an N-hydroxypiperidine derivative of verapamil, on the modulation of myocardial tissue… CONTINUE READING
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