Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery.

@article{Suleiman2011CardioplegicST,
  title={Cardioplegic strategies to protect the hypertrophic heart during cardiac surgery.},
  author={M-Saadeh Suleiman and Michael L. Hancock and Ranjeet Shukla and Chanaka Rajakaruna and Gianni Angelini},
  journal={Perfusion},
  year={2011},
  volume={26 Suppl 1},
  pages={48-56}
}
Cardioplegic arrest and cardiopulmonary bypass are key triggers of myocardial injury during aortic valve surgery. Cardioplegic ischaemic arrest is associated with disruption to metabolic and ionic homeostasis in cardiomyocytes. These changes predispose the heart to reperfusion injury caused by elevated intracellular reactive oxygen species and calcium. Cardiopulmonary bypass is associated with an inflammatory response that can generate systemic oxidative stress which, in turn, provokes further… CONTINUE READING