Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.

@article{Olivetti1991CardiomyopathyOT,
  title={Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.},
  author={Giorgio Olivetti and M Melissari and Joseph M. Capasso and Piero Anversa},
  journal={Circulation research},
  year={1991},
  volume={68 6},
  pages={1560-8}
}
To determine the effects of aging on the human myocardium, 67 hearts were obtained from individuals who died from causes other than cardiovascular disease. The age interval examined was 17-90 years. Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte nuclei/yr in the left and right ventricular myocardium, respectively. This loss in muscle mass was accompanied by a progressive increase in myocyte cell volume per nucleus in both… CONTINUE READING

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Effects of age on the contractile performance and quantitative structural characteristics of left and right myocardium in Sprague-Dawley rats

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