Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.

@article{Seebohm2009CardiomyopathyMR,
  title={Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.},
  author={Benjamin Seebohm and Faramarz Matinmehr and J{\"u}rgen K{\"o}hler and Antonio Francino and Fransisco Navarro-Lop{\'e}z and Arnaud Perrot and Cevdet Ozcelik and Wayne J. McKenna and Bernhard Brenner and Torsten Kraft},
  journal={Biophysical journal},
  year={2009},
  volume={97 3},
  pages={
          806-24
        }
}
The ability of myosin to generate motile forces is based on elastic distortion of a structural element of the actomyosin complex (cross-bridge) that allows strain to develop before filament sliding. Addressing the question, which part of the actomyosin complex experiences main elastic distortion, we suggested previously that the converter domain might be the most compliant region of the myosin head domain. Here we test this proposal by studying functional effects of naturally occurring missense… CONTINUE READING

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