Cardiomyopathy in transgenic myf5 mice.


To explore the compatibility of skeletal and cardiac programs of gene expression, transgenic mice that express a skeletal muscle myogenic regulator, bmyf5, in the heart were analyzed. These mice develop a severe cardiomyopathy and exhibit a significantly shorter life span than do their nontransgenic littermates. The transgene was expressed from day 7.5 post… (More)


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@article{Edwards1996CardiomyopathyIT, title={Cardiomyopathy in transgenic myf5 mice.}, author={Jan Edwards and Greg Lyons and Bruce K. Micales and Arun Malhotra and Stewart A. Factor and L. A. Leinwand}, journal={Circulation research}, year={1996}, volume={78 3}, pages={379-87} }